{"id":2602,"date":"2024-11-26T02:07:47","date_gmt":"2024-11-25T22:37:47","guid":{"rendered":"https:\/\/evamed.ir\/cervical-cancer\/?page_id=2602"},"modified":"2024-12-05T12:31:44","modified_gmt":"2024-12-05T09:01:44","slug":"diagnosing-and-staging-guideline","status":"publish","type":"page","link":"https:\/\/evamed.ir\/cervical-cancer\/diagnosing-and-staging-guideline\/","title":{"rendered":"Diagnosing and Staging-guideline"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2602\" class=\"elementor elementor-2602\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-41ddc08 e-con-full e-flex e-con e-parent\" data-id=\"41ddc08\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-642e88d elementor-widget elementor-widget-spacer\" data-id=\"642e88d\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c0954bd e-flex e-con-boxed e-con e-parent\" data-id=\"c0954bd\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-96b1ba6 e-con-full e-flex e-con e-child\" data-id=\"96b1ba6\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d9e5071 e-con-full e-flex e-con e-child\" data-id=\"d9e5071\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3f0dbd0 elementor-widget elementor-widget-hotspot\" data-id=\"3f0dbd0\" data-element_type=\"widget\" data-settings=\"{&quot;hotspot&quot;:[{&quot;_id&quot;:&quot;6490865&quot;,&quot;hotspot_icon&quot;:{&quot;value&quot;:&quot;fas fa-info-circle&quot;,&quot;library&quot;:&quot;fa-solid&quot;},&quot;hotspot_custom_size&quot;:&quot;&quot;,&quot;hotspot_tooltip_content&quot;:&quot;&lt;ol&gt;&lt;li&gt;\\u062f\\u0631 \\u0627\\u0648\\u0644\\u06cc\\u0646 \\u0645\\u0631\\u062d\\u0644\\u0647\\u200c\\u06cc \\u062a\\u0634\\u062e\\u06cc\\u0635 \\u0633\\u0631\\u0637\\u0627\\u0646 \\u067e\\u0633\\u062a\\u0627\\u0646 \\u0645\\u062a\\u0627\\u0633\\u062a\\u0627\\u062a\\u06cc\\u06a9\\u060c \\u0628\\u06cc\\u0648\\u067e\\u0633\\u06cc \\u0628\\u0627\\u06cc\\u062f \\u0628\\u0631\\u0627\\u06cc \\u062a\\u0627\\u06cc\\u06cc\\u062f \\u0628\\u0627\\u0641\\u062a\\u200c\\u0634\\u0646\\u0627\\u0633\\u06cc \\u0648 \\u0627\\u0631\\u0632\\u06cc\\u0627\\u0628\\u06cc \\u0645\\u062c\\u062f\\u062f \\u0628\\u06cc\\u0648\\u0644\\u0648\\u0698\\u06cc \\u062a\\u0648\\u0645\\u0648\\u0631 \\u0627\\u0646\\u062c\\u0627\\u0645 \\u0634\\u0648\\u062f (ER\\u060c PgR\\u060c HER2).&lt;\\\/li&gt;&lt;li&gt;\\u0633\\u0627\\u06cc\\u0631 \\u0646\\u0634\\u0627\\u0646\\u06af\\u0631\\u0647\\u0627\\u06cc \\u0632\\u06cc\\u0633\\u062a\\u06cc \\u0645\\u0631\\u062a\\u0628\\u0637 \\u0627\\u0632 \\u0646\\u0638\\u0631 \\u062f\\u0631\\u0645\\u0627\\u0646\\u06cc \\u06a9\\u0647 \\u0628\\u0627\\u06cc\\u062f \\u0628\\u0647 \\u0639\\u0646\\u0648\\u0627\\u0646 \\u0628\\u062e\\u0634\\u06cc \\u0627\\u0632 \\u0639\\u0645\\u0644\\u06a9\\u0631\\u062f \\u0628\\u0627\\u0644\\u06cc\\u0646\\u06cc \\u0645\\u0639\\u0645\\u0648\\u0644 \\u0627\\u0631\\u0632\\u06cc\\u0627\\u0628\\u06cc \\u0634\\u0648\\u0646\\u062f \\u0639\\u0628\\u0627\\u0631\\u062a\\u0646\\u062f \\u0627\\u0632: \\u0648\\u0636\\u0639\\u06cc\\u062a \\u062c\\u0647\\u0634\\u200c\\u0647\\u0627\\u06cc \\u0698\\u0631\\u0645\\u06cc\\u0646\\u0627\\u0644 BRCA1\\\/2 (gBRCAm) \\u062f\\u0631 \\u0633\\u0631\\u0637\\u0627\\u0646 \\u067e\\u0633\\u062a\\u0627\\u0646 \\u0645\\u062a\\u0627\\u0633\\u062a\\u0627\\u062a\\u06cc\\u06a9 \\u0627\\u0632 \\u0646\\u0648\\u0639 HER2-\\u0645\\u0646\\u0641\\u06cc\\u060c \\u0648\\u0636\\u0639\\u06cc\\u062a PD-L1 \\u062f\\u0631 \\u0633\\u0631\\u0637\\u0627\\u0646 \\u067e\\u0633\\u062a\\u0627\\u0646 \\u0633\\u0647 \\u06af\\u0627\\u0646\\u0647 \\u0645\\u0646\\u0641\\u06cc (TNBC)\\u060c \\u0648\\u0636\\u0639\\u06cc\\u062a \\u062c\\u0647\\u0634 \\u062f\\u0631 \\u0698\\u0646 PIK3CA \\u0648 \\u06af\\u06cc\\u0631\\u0646\\u062f\\u0647 \\u0627\\u0633\\u062a\\u0631\\u0648\\u0698\\u0646 1 (ESR1) \\u062f\\u0631 \\u0633\\u0631\\u0637\\u0627\\u0646 \\u067e\\u0633\\u062a\\u0627\\u0646 \\u0645\\u062a\\u0627\\u0633\\u062a\\u0627\\u062a\\u06cc\\u06a9 \\u0627\\u0632 \\u0646\\u0648\\u0639 HER2-\\u0645\\u0646\\u0641\\u06cc\\u060c ER\\\/PgR-\\u0645\\u062b\\u0628\\u062a.&lt;\\\/li&gt;&lt;li&gt;\\u067e\\u0631\\u0648\\u0641\\u0627\\u06cc\\u0644\\u06cc\\u0646\\u06af \\u0698\\u0646\\u0648\\u0645\\u06cc \\u0648 \\u0622\\u0632\\u0645\\u0627\\u06cc\\u0634\\u200c\\u0647\\u0627\\u06cc \\u062a\\u0634\\u062e\\u06cc\\u0635\\u06cc \\u0628\\u06cc\\u0634\\u062a\\u0631 \\u0628\\u0647 \\u0639\\u0646\\u0648\\u0627\\u0646 \\u0645\\u062b\\u0627\\u0644 \\u0631\\u0648\\u06cc \\u0628\\u0627\\u0641\\u062a \\u062a\\u0648\\u0645\\u0648\\u0631\\u06cc \\u06cc\\u0627 DNA \\u062a\\u0648\\u0645\\u0648\\u0631\\u06cc \\u062f\\u0631 \\u06af\\u0631\\u062f\\u0634 (ctDNA) \\u062a\\u0646\\u0647\\u0627 \\u062f\\u0631 \\u0635\\u0648\\u0631\\u062a\\u06cc \\u0645\\u06cc\\u200c\\u062a\\u0648\\u0627\\u0646\\u062f \\u0628\\u0647 \\u0639\\u0646\\u0648\\u0627\\u0646 \\u0628\\u062e\\u0634\\u06cc \\u0627\\u0632 \\u0641\\u0631\\u0627\\u06cc\\u0646\\u062f \\u0628\\u0627\\u0644\\u06cc\\u0646\\u06cc \\u0645\\u0639\\u0645\\u0648\\u0644 \\u0627\\u0646\\u062c\\u0627\\u0645 \\u0634\\u0648\\u062f \\u06a9\\u0647 \\u06cc\\u0627 \\u0631\\u0648\\u06cc\\u06a9\\u0631\\u062f \\u062f\\u0631\\u0645\\u0627\\u0646 \\u0631\\u0627 \\u062a\\u063a\\u06cc\\u06cc\\u0631 \\u062f\\u0647\\u062f \\u06cc\\u0627 \\u0622\\u0646\\u200c\\u06a9\\u0647 \\u0628\\u06cc\\u0645\\u0627\\u0631 \\u0628\\u062a\\u0648\\u0627\\u0646\\u062f \\u0627\\u06cc\\u0646 \\u062e\\u062f\\u0645\\u0627\\u062a \\u0631\\u0627 \\u062f\\u0631 \\u0642\\u0627\\u0644\\u0628 \\u06a9\\u0627\\u0631\\u0622\\u0632\\u0645\\u0627\\u06cc\\u06cc\\u200c\\u0647\\u0627\\u06cc \\u0628\\u0627\\u0644\\u06cc\\u0646\\u06cc \\u062f\\u0631\\u06cc\\u0627\\u0641\\u062a \\u06a9\\u0646\\u062f.&lt;\\\/li&gt;&lt;li&gt;\\u0628\\u0647 \\u062f\\u0644\\u06cc\\u0644 \\u0645\\u062d\\u062f\\u0648\\u062f\\u06cc\\u062a\\u200c\\u0647\\u0627\\u06cc \\u0641\\u0646\\u06cc \\u0634\\u0646\\u0627\\u0633\\u0627\\u06cc\\u06cc \\u0646\\u0634\\u0627\\u0646\\u06af\\u0631\\u0647\\u0627\\u06cc \\u0632\\u06cc\\u0633\\u062a\\u06cc \\u062f\\u0631 \\u0628\\u0627\\u0641\\u062a\\u200c\\u0647\\u0627\\u06cc \\u062f\\u06a9\\u0644\\u0633\\u06cc\\u0641\\u0627\\u06cc\\u200c\\u0634\\u062f\\u0647\\u060c \\u062a\\u0627 \\u062d\\u062f \\u0627\\u0645\\u06a9\\u0627\\u0646 \\u0627\\u0632 \\u0628\\u06cc\\u0648\\u067e\\u0633\\u06cc \\u0645\\u062a\\u0627\\u0633\\u062a\\u0627\\u0632\\u0647\\u0627\\u06cc \\u0627\\u0633\\u062a\\u062e\\u0648\\u0627\\u0646\\u06cc \\u0628\\u0627\\u06cc\\u062f \\u0627\\u062c\\u062a\\u0646\\u0627\\u0628 \\u0634\\u0648\\u062f. \\u0632\\u0645\\u0627\\u0646\\u06cc \\u06a9\\u0647 ER\\\/PgR \\u06cc\\u0627 HER2 \\u0628\\u062f\\u0648\\u0646 \\u062f\\u0631 \\u0646\\u0638\\u0631 \\u06af\\u0631\\u0641\\u062a\\u0646 \\u0632\\u0645\\u0627\\u0646\\u060c \\u062d\\u062f\\u0627\\u0642\\u0644 \\u062f\\u0631 \\u06cc\\u06a9 \\u0646\\u0645\\u0648\\u0646\\u0647\\u200c\\u0628\\u0631\\u062f\\u0627\\u0631\\u06cc \\u0645\\u062b\\u0628\\u062a \\u0628\\u0627\\u0634\\u062f\\u060c \\u0627\\u0633\\u062a\\u0641\\u0627\\u062f\\u0647 \\u0627\\u0632 ET \\u06cc\\u0627 \\u062f\\u0631\\u0645\\u0627\\u0646 \\u0636\\u062f HER2 \\u0628\\u0627\\u06cc\\u062f \\u062f\\u0631 \\u0646\\u0638\\u0631 \\u06af\\u0631\\u0641\\u062a\\u0647 \\u0634\\u0648\\u062f. \\u0646\\u0627\\u0647\\u0645\\u06af\\u0648\\u0646\\u06cc \\u062a\\u0648\\u0645\\u0648\\u0631 \\u0628\\u0627\\u06cc\\u062f \\u0628\\u0631\\u0627\\u06cc \\u0647\\u0631 \\u062e\\u0637 \\u062f\\u0631\\u0645\\u0627\\u0646\\u06cc \\u062c\\u062f\\u06cc\\u062f \\u062f\\u0631 \\u0646\\u0638\\u0631 \\u06af\\u0631\\u0641\\u062a\\u0647 \\u0634\\u0648\\u062f \\u0648 \\u0646\\u0645\\u0648\\u0646\\u0647\\u200c\\u0628\\u0631\\u062f\\u0627\\u0631\\u06cc \\u0645\\u062c\\u062f\\u062f \\u0645\\u0645\\u06a9\\u0646 \\u0627\\u0633\\u062a \\u062f\\u0631 \\u0645\\u0648\\u0627\\u0631\\u062f \\u067e\\u0627\\u0633\\u062e \\u0645\\u062e\\u062a\\u0644\\u0637 \\u0645\\u0646\\u0627\\u0633\\u0628 \\u0628\\u0627\\u0634\\u062f.&lt;\\\/li&gt;&lt;li&gt;HER2-low \\u0628\\u0627 IHC 2+ \\u0648 \\u0646\\u062a\\u06cc\\u062c\\u0647 ISH \\u0645\\u0646\\u0641\\u06cc \\u06cc\\u0627 \\u0628\\u0627 IHC 1+ \\u0645\\u0634\\u062e\\u0635 \\u0645\\u06cc\\u200c\\u0634\\u0648\\u062f.&lt;\\\/li&gt;&lt;\\\/ol&gt;&quot;,&quot;hotspot_offset_x&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:71,&quot;sizes&quot;:[]},&quot;hotspot_offset_y&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:16,&quot;sizes&quot;:[]},&quot;hotspot_tooltip_position&quot;:&quot;yes&quot;,&quot;hotspot_position&quot;:&quot;top&quot;,&quot;hotspot_tooltip_width&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:409,&quot;sizes&quot;:[]},&quot;hotspot_tooltip_text_wrap&quot;:&quot;yes&quot;,&quot;hotspot_label&quot;:&quot;&quot;,&quot;hotspot_link&quot;:{&quot;url&quot;:&quot;&quot;,&quot;is_external&quot;:&quot;&quot;,&quot;nofollow&quot;:&quot;&quot;,&quot;custom_attributes&quot;:&quot;&quot;},&quot;hotspot_horizontal&quot;:&quot;right&quot;,&quot;hotspot_vertical&quot;:&quot;top&quot;,&quot;hotspot_position_tablet&quot;:&quot;&quot;,&quot;hotspot_position_mobile&quot;:&quot;&quot;,&quot;hotspot_icon_position&quot;:null,&quot;hotspot_icon_spacing&quot;:null,&quot;hotspot_width&quot;:null,&quot;hotspot_height&quot;:null,&quot;hotspot_offset_x_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;hotspot_offset_x_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;hotspot_offset_y_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;hotspot_offset_y_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;hotspot_tooltip_width_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;hotspot_tooltip_width_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}],&quot;tooltip_position&quot;:&quot;right&quot;,&quot;hotspot_sequenced_animation&quot;:&quot;no&quot;,&quot;tooltip_trigger&quot;:&quot;click&quot;,&quot;tooltip_animation&quot;:&quot;e-hotspot--fade-in-out&quot;}\" data-widget_type=\"hotspot.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/evamed.ir\/cervical-cancer\/wp-content\/uploads\/2024\/11\/fig1.jpg\" title=\"\" alt=\"\" loading=\"lazy\" \/>\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-6490865  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<ol><li>\u062f\u0631 \u0627\u0648\u0644\u06cc\u0646 \u0645\u0631\u062d\u0644\u0647\u200c\u06cc \u062a\u0634\u062e\u06cc\u0635 \u0633\u0631\u0637\u0627\u0646 \u067e\u0633\u062a\u0627\u0646 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9\u060c \u0628\u06cc\u0648\u067e\u0633\u06cc \u0628\u0627\u06cc\u062f \u0628\u0631\u0627\u06cc \u062a\u0627\u06cc\u06cc\u062f \u0628\u0627\u0641\u062a\u200c\u0634\u0646\u0627\u0633\u06cc \u0648 \u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u0645\u062c\u062f\u062f \u0628\u06cc\u0648\u0644\u0648\u0698\u06cc \u062a\u0648\u0645\u0648\u0631 \u0627\u0646\u062c\u0627\u0645 \u0634\u0648\u062f (ER\u060c PgR\u060c HER2).<\/li><li>\u0633\u0627\u06cc\u0631 \u0646\u0634\u0627\u0646\u06af\u0631\u0647\u0627\u06cc \u0632\u06cc\u0633\u062a\u06cc \u0645\u0631\u062a\u0628\u0637 \u0627\u0632 \u0646\u0638\u0631 \u062f\u0631\u0645\u0627\u0646\u06cc \u06a9\u0647 \u0628\u0627\u06cc\u062f \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u0628\u062e\u0634\u06cc \u0627\u0632 \u0639\u0645\u0644\u06a9\u0631\u062f \u0628\u0627\u0644\u06cc\u0646\u06cc \u0645\u0639\u0645\u0648\u0644 \u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u0634\u0648\u0646\u062f \u0639\u0628\u0627\u0631\u062a\u0646\u062f \u0627\u0632: \u0648\u0636\u0639\u06cc\u062a \u062c\u0647\u0634\u200c\u0647\u0627\u06cc \u0698\u0631\u0645\u06cc\u0646\u0627\u0644 BRCA1\/2 (gBRCAm) \u062f\u0631 \u0633\u0631\u0637\u0627\u0646 \u067e\u0633\u062a\u0627\u0646 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 \u0627\u0632 \u0646\u0648\u0639 HER2-\u0645\u0646\u0641\u06cc\u060c \u0648\u0636\u0639\u06cc\u062a PD-L1 \u062f\u0631 \u0633\u0631\u0637\u0627\u0646 \u067e\u0633\u062a\u0627\u0646 \u0633\u0647 \u06af\u0627\u0646\u0647 \u0645\u0646\u0641\u06cc (TNBC)\u060c \u0648\u0636\u0639\u06cc\u062a \u062c\u0647\u0634 \u062f\u0631 \u0698\u0646 PIK3CA \u0648 \u06af\u06cc\u0631\u0646\u062f\u0647 \u0627\u0633\u062a\u0631\u0648\u0698\u0646 1 (ESR1) \u062f\u0631 \u0633\u0631\u0637\u0627\u0646 \u067e\u0633\u062a\u0627\u0646 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 \u0627\u0632 \u0646\u0648\u0639 HER2-\u0645\u0646\u0641\u06cc\u060c ER\/PgR-\u0645\u062b\u0628\u062a.<\/li><li>\u067e\u0631\u0648\u0641\u0627\u06cc\u0644\u06cc\u0646\u06af \u0698\u0646\u0648\u0645\u06cc \u0648 \u0622\u0632\u0645\u0627\u06cc\u0634\u200c\u0647\u0627\u06cc \u062a\u0634\u062e\u06cc\u0635\u06cc \u0628\u06cc\u0634\u062a\u0631 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u0645\u062b\u0627\u0644 \u0631\u0648\u06cc \u0628\u0627\u0641\u062a \u062a\u0648\u0645\u0648\u0631\u06cc \u06cc\u0627 DNA \u062a\u0648\u0645\u0648\u0631\u06cc \u062f\u0631 \u06af\u0631\u062f\u0634 (ctDNA) \u062a\u0646\u0647\u0627 \u062f\u0631 \u0635\u0648\u0631\u062a\u06cc \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u0628\u062e\u0634\u06cc \u0627\u0632 \u0641\u0631\u0627\u06cc\u0646\u062f \u0628\u0627\u0644\u06cc\u0646\u06cc \u0645\u0639\u0645\u0648\u0644 \u0627\u0646\u062c\u0627\u0645 \u0634\u0648\u062f \u06a9\u0647 \u06cc\u0627 \u0631\u0648\u06cc\u06a9\u0631\u062f \u062f\u0631\u0645\u0627\u0646 \u0631\u0627 \u062a\u063a\u06cc\u06cc\u0631 \u062f\u0647\u062f \u06cc\u0627 \u0622\u0646\u200c\u06a9\u0647 \u0628\u06cc\u0645\u0627\u0631 \u0628\u062a\u0648\u0627\u0646\u062f \u0627\u06cc\u0646 \u062e\u062f\u0645\u0627\u062a \u0631\u0627 \u062f\u0631 \u0642\u0627\u0644\u0628 \u06a9\u0627\u0631\u0622\u0632\u0645\u0627\u06cc\u06cc\u200c\u0647\u0627\u06cc \u0628\u0627\u0644\u06cc\u0646\u06cc \u062f\u0631\u06cc\u0627\u0641\u062a \u06a9\u0646\u062f.<\/li><li>\u0628\u0647 \u062f\u0644\u06cc\u0644 \u0645\u062d\u062f\u0648\u062f\u06cc\u062a\u200c\u0647\u0627\u06cc \u0641\u0646\u06cc \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u0646\u0634\u0627\u0646\u06af\u0631\u0647\u0627\u06cc \u0632\u06cc\u0633\u062a\u06cc \u062f\u0631 \u0628\u0627\u0641\u062a\u200c\u0647\u0627\u06cc \u062f\u06a9\u0644\u0633\u06cc\u0641\u0627\u06cc\u200c\u0634\u062f\u0647\u060c \u062a\u0627 \u062d\u062f \u0627\u0645\u06a9\u0627\u0646 \u0627\u0632 \u0628\u06cc\u0648\u067e\u0633\u06cc \u0645\u062a\u0627\u0633\u062a\u0627\u0632\u0647\u0627\u06cc \u0627\u0633\u062a\u062e\u0648\u0627\u0646\u06cc \u0628\u0627\u06cc\u062f \u0627\u062c\u062a\u0646\u0627\u0628 \u0634\u0648\u062f. \u0632\u0645\u0627\u0646\u06cc \u06a9\u0647 ER\/PgR \u06cc\u0627 HER2 \u0628\u062f\u0648\u0646 \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0646 \u0632\u0645\u0627\u0646\u060c \u062d\u062f\u0627\u0642\u0644 \u062f\u0631 \u06cc\u06a9 \u0646\u0645\u0648\u0646\u0647\u200c\u0628\u0631\u062f\u0627\u0631\u06cc \u0645\u062b\u0628\u062a \u0628\u0627\u0634\u062f\u060c \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 ET \u06cc\u0627 \u062f\u0631\u0645\u0627\u0646 \u0636\u062f HER2 \u0628\u0627\u06cc\u062f \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f. \u0646\u0627\u0647\u0645\u06af\u0648\u0646\u06cc \u062a\u0648\u0645\u0648\u0631 \u0628\u0627\u06cc\u062f \u0628\u0631\u0627\u06cc \u0647\u0631 \u062e\u0637 \u062f\u0631\u0645\u0627\u0646\u06cc \u062c\u062f\u06cc\u062f \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f \u0648 \u0646\u0645\u0648\u0646\u0647\u200c\u0628\u0631\u062f\u0627\u0631\u06cc \u0645\u062c\u062f\u062f \u0645\u0645\u06a9\u0646 \u0627\u0633\u062a \u062f\u0631 \u0645\u0648\u0627\u0631\u062f \u067e\u0627\u0633\u062e \u0645\u062e\u062a\u0644\u0637 \u0645\u0646\u0627\u0633\u0628 \u0628\u0627\u0634\u062f.<\/li><li>HER2-low \u0628\u0627 IHC 2+ \u0648 \u0646\u062a\u06cc\u062c\u0647 ISH \u0645\u0646\u0641\u06cc \u06cc\u0627 \u0628\u0627 IHC 1+ \u0645\u0634\u062e\u0635 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/li><\/ol>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f388b57 e-con-full e-flex e-con e-child\" data-id=\"f388b57\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-35adc15 e-flex e-con-boxed e-con e-parent\" data-id=\"35adc15\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-9fe15e0 e-con-full e-flex e-con e-child\" data-id=\"9fe15e0\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4e3689c e-con-full e-flex e-con e-child\" data-id=\"4e3689c\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18d4f99 elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"18d4f99\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7b944a5 elementor-widget elementor-widget-text-editor\" data-id=\"7b944a5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: left;\">AI, aromatase inhibitor; CNS, central nervous system; CT, computed tomography; ER, estrogen receptor; ESCAT, ESMO Scale for Clinical Actionability of Molecular Targets;\u00a0<em>ESR1<\/em>,\u00a0<em>estrogen receptor 1<\/em>;\u00a0<em>gBRCAm<\/em>, germline\u00a0<em>BRCA1\/2<\/em>\u00a0mutation; HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; ISH,\u00a0<em>in situ<\/em>\u00a0hybridisation; MBC, metastatic breast cancer; MSI, microsatellite instability;\u00a0<em>NTRK<\/em>,\u00a0<em>neurotrophic tyrosine receptor kinase<\/em>;\u00a0<em>PALB2<\/em>,\u00a0<em>partner and localiser of BRCA2<\/em>; PD-L1, programmed death-ligand 1; PET, positron emission tomography; PgR, progesterone receptor;\u00a0<em>PIK3CA<\/em>,\u00a0<em>phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha<\/em>; TMB, tumour mutation burden; TNBC, triple-negative breast cancer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d936c17 e-con-full e-flex e-con e-child\" data-id=\"d936c17\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u062f\u0631 \u0627\u0648\u0644\u06cc\u0646 \u0645\u0631\u062d\u0644\u0647\u200c\u06cc \u062a\u0634\u062e\u06cc\u0635 \u0633\u0631\u0637\u0627\u0646 \u067e\u0633\u062a\u0627\u0646 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9\u060c \u0628\u06cc\u0648\u067e\u0633\u06cc \u0628\u0627\u06cc\u062f \u0628\u0631\u0627\u06cc \u062a\u0627\u06cc\u06cc\u062f \u0628\u0627\u0641\u062a\u200c\u0634\u0646\u0627\u0633\u06cc \u0648 \u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u0645\u062c\u062f\u062f \u0628\u06cc\u0648\u0644\u0648\u0698\u06cc \u062a\u0648\u0645\u0648\u0631 \u0627\u0646\u062c\u0627\u0645 \u0634\u0648\u062f (ER\u060c PgR\u060c HER2). \u0633\u0627\u06cc\u0631 \u0646\u0634\u0627\u0646\u06af\u0631\u0647\u0627\u06cc \u0632\u06cc\u0633\u062a\u06cc \u0645\u0631\u062a\u0628\u0637 \u0627\u0632 \u0646\u0638\u0631 \u062f\u0631\u0645\u0627\u0646\u06cc \u06a9\u0647 \u0628\u0627\u06cc\u062f \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u0628\u062e\u0634\u06cc \u0627\u0632 \u0639\u0645\u0644\u06a9\u0631\u062f \u0628\u0627\u0644\u06cc\u0646\u06cc \u0645\u0639\u0645\u0648\u0644 \u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u0634\u0648\u0646\u062f \u0639\u0628\u0627\u0631\u062a\u0646\u062f \u0627\u0632: \u0648\u0636\u0639\u06cc\u062a \u062c\u0647\u0634\u200c\u0647\u0627\u06cc \u0698\u0631\u0645\u06cc\u0646\u0627\u0644 BRCA1\/2 (gBRCAm) \u062f\u0631 \u0633\u0631\u0637\u0627\u0646 \u067e\u0633\u062a\u0627\u0646 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 \u0627\u0632 \u0646\u0648\u0639 HER2-\u0645\u0646\u0641\u06cc\u060c \u0648\u0636\u0639\u06cc\u062a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2602","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/pages\/2602","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/comments?post=2602"}],"version-history":[{"count":58,"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/pages\/2602\/revisions"}],"predecessor-version":[{"id":3073,"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/pages\/2602\/revisions\/3073"}],"wp:attachment":[{"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/media?parent=2602"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}