{"id":2663,"date":"2024-11-26T02:44:07","date_gmt":"2024-11-25T23:14:07","guid":{"rendered":"https:\/\/evamed.ir\/cervical-cancer\/?page_id=2663"},"modified":"2024-12-05T12:05:07","modified_gmt":"2024-12-05T08:35:07","slug":"er-positive-her2-negative-breast-cancerchemotherapy","status":"publish","type":"page","link":"https:\/\/evamed.ir\/cervical-cancer\/er-positive-her2-negative-breast-cancerchemotherapy\/","title":{"rendered":"ER-positive HER2-negative\u200b Breast Cancer\u200bChemotherapy"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2663\" class=\"elementor elementor-2663\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bfc0484 e-flex e-con-boxed e-con e-parent\" data-id=\"bfc0484\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7a28edf elementor-widget elementor-widget-spacer\" data-id=\"7a28edf\" 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\\\/&gt;&lt;\\\/li&gt;&lt;\\\/ol&gt;&lt;p&gt;&lt;strong&gt;Trastuzumab Deruxtecan for HER2-low&lt;\\\/strong&gt;&lt;\\\/p&gt;&lt;ol start=\\&quot;2\\&quot;&gt;&lt;li&gt;Trastuzumab deruxtecan \\u0628\\u0627\\u06cc\\u062f \\u0628\\u0631\\u0627\\u06cc \\u0628\\u06cc\\u0645\\u0627\\u0631\\u0627\\u0646 \\u0645\\u0628\\u062a\\u0644\\u0627 \\u0628\\u0647 \\u0633\\u0631\\u0637\\u0627\\u0646 \\u067e\\u0633\\u062a\\u0627\\u0646 \\u0645\\u062a\\u0627\\u0633\\u062a\\u0627\\u062a\\u06cc\\u06a9 HER2-low \\u067e\\u0633 \\u0627\\u0632 \\u062d\\u062f\\u0627\\u0642\\u0644 \\u06cc\\u06a9 \\u062e\\u0637 ChT \\u062f\\u0631 \\u0646\\u0638\\u0631 \\u06af\\u0631\\u0641\\u062a\\u0647 \\u0634\\u0648\\u062f.&lt;img class=\\&quot;alignnone size-medium wp-image-3049\\&quot; src=\\&quot;https:\\\/\\\/evamed.ir\\\/cervical-cancer\\\/wp-content\\\/uploads\\\/2024\\\/12\\\/32-500x50.png\\&quot; alt=\\&quot;\\&quot; width=\\&quot;500\\&quot; height=\\&quot;50\\&quot; \\\/&gt;&lt;\\\/li&gt;&lt;\\\/ol&gt;&lt;p&gt;&lt;strong&gt;Chemotherapy&lt;\\\/strong&gt;&lt;\\\/p&gt;&lt;ol start=\\&quot;3\\&quot;&gt;&lt;li&gt;\\u0628\\u06cc\\u0645\\u0627\\u0631\\u0627\\u0646 \\u0645\\u0628\\u062a\\u0644\\u0627 \\u0628\\u0647 \\u062a\\u0648\\u0645\\u0648\\u0631\\u0647\\u0627\\u06cc\\u06cc \\u06a9\\u0647 \\u0628\\u0647 \\u0647\\u0648\\u0631\\u0645\\u0648\\u0646\\u200c\\u062f\\u0631\\u0645\\u0627\\u0646\\u06cc \\u0645\\u0642\\u0627\\u0648\\u0645 \\u0647\\u0633\\u062a\\u0646\\u062f \\u0628\\u0627\\u06cc\\u062f \\u0628\\u0631\\u0627\\u06cc ChT \\u062f\\u0631 \\u0646\\u0638\\u0631 \\u06af\\u0631\\u0641\\u062a\\u0647 \\u0634\\u0648\\u0646\\u062f.&lt;\\\/li&gt;&lt;li&gt;\\u0628\\u0647 \\u0637\\u0648\\u0631 \\u06a9\\u0644\\u06cc ChT \\u062a\\u06a9\\u200c\\u0639\\u0627\\u0645\\u0644\\u06cc \\u0645\\u062a\\u0648\\u0627\\u0644\\u06cc \\u0628\\u0631 \\u0627\\u0633\\u062a\\u0631\\u0627\\u062a\\u0698\\u06cc\\u200c\\u0647\\u0627\\u06cc \\u062a\\u0631\\u06a9\\u06cc\\u0628\\u06cc \\u062a\\u0631\\u062c\\u06cc\\u062d \\u062f\\u0627\\u062f\\u0647 \\u0645\\u06cc\\u200c\\u0634\\u0648\\u062f. \\u062f\\u0631 \\u0628\\u06cc\\u0645\\u0627\\u0631\\u0627\\u0646\\u06cc \\u06a9\\u0647 \\u0628\\u0647 \\u062f\\u0644\\u06cc\\u0644 \\u0646\\u0627\\u0631\\u0633\\u0627\\u06cc\\u06cc \\u0642\\u0631\\u06cc\\u0628 \\u0627\\u0644\\u0648\\u0642\\u0648\\u0639 \\u0627\\u0646\\u062f\\u0627\\u0645 \\u0628\\u0647 \\u067e\\u0627\\u0633\\u062e \\u0633\\u0631\\u06cc\\u0639 \\u0646\\u06cc\\u0627\\u0632 \\u0627\\u0633\\u062a\\u060c ChT \\u062a\\u0631\\u06a9\\u06cc\\u0628\\u06cc \\u062a\\u0631\\u062c\\u06cc\\u062d \\u062f\\u0627\\u062f\\u0647 \\u0645\\u06cc\\u200c\\u0634\\u0648\\u062f.&lt;\\\/li&gt;&lt;li&gt;\\u062f\\u0627\\u0631\\u0648\\u0647\\u0627\\u06cc \\u0645\\u0648\\u062c\\u0648\\u062f \\u0628\\u0631\\u0627\\u06cc ChT \\u062a\\u06a9 \\u0639\\u0627\\u0645\\u0644\\u06cc \\u0639\\u0628\\u0627\\u0631\\u062a\\u0646\\u062f \\u0627\\u0632 \\u0622\\u0646\\u062a\\u0631\\u0627\\u0633\\u0627\\u06cc\\u06a9\\u0644\\u06cc\\u0646\\u200c\\u0647\\u0627\\u060c \\u062a\\u0627\\u06a9\\u0633\\u0627\\u0646\\u200c\\u0647\\u0627\\u060c \\u06a9\\u067e\\u0633\\u06cc\\u062a\\u0627\\u0628\\u06cc\\u0646\\u060c \\u0627\\u0631\\u06cc\\u0628\\u0648\\u0644\\u06cc\\u0646\\u060c \\u0648\\u06cc\\u0646\\u0648\\u0631\\u0644\\u0628\\u06cc\\u0646\\u060c \\u067e\\u0644\\u0627\\u062a\\u06cc\\u0646 \\u0648 \\u0633\\u0627\\u06cc\\u0631 \\u0639\\u0648\\u0627\\u0645\\u0644.&lt;\\\/li&gt;&lt;li&gt;\\u0686\\u0627\\u0644\\u0634 \\u0645\\u062c\\u062f\\u062f \\u0628\\u0627 \\u0622\\u0646\\u062a\\u0631\\u0627\\u0633\\u0627\\u06cc\\u06a9\\u0644\\u06cc\\u0646\\u200c\\u0647\\u0627 \\u06cc\\u0627 \\u062a\\u0627\\u06a9\\u0633\\u0627\\u0646\\u200c\\u0647\\u0627 \\u062f\\u0631 \\u0628\\u06cc\\u0645\\u0627\\u0631\\u0627\\u0646 \\u0628\\u0627 DFI \\u226512 \\u0645\\u0627\\u0647 \\u0627\\u0645\\u06a9\\u0627\\u0646\\u200c\\u067e\\u0630\\u06cc\\u0631 \\u0627\\u0633\\u062a. \\u062f\\u0631 \\u0635\\u0648\\u0631\\u062a \\u0627\\u0645\\u06a9\\u0627\\u0646\\u060c \\u0627\\u0633\\u062a\\u0641\\u0627\\u062f\\u0647 \\u0627\\u0632 \\u0622\\u0646\\u062a\\u0631\\u0627\\u0633\\u0627\\u06cc\\u06a9\\u0644\\u06cc\\u0646\\u200c\\u0647\\u0627\\u06cc \\u0644\\u06cc\\u067e\\u0648\\u0632\\u0648\\u0645\\u06cc \\u06cc\\u0627 \\u067e\\u0627\\u06a9\\u0644\\u06cc\\u062a\\u0627\\u06a9\\u0633\\u0644 \\u0645\\u062a\\u0635\\u0644 \\u0628\\u0647 \\u067e\\u0631\\u0648\\u062a\\u0626\\u06cc\\u0646 \\u0645\\u0645\\u06a9\\u0646 \\u0627\\u0633\\u062a \\u0628\\u0631\\u0627\\u06cc \\u0686\\u0627\\u0644\\u0634 \\u0645\\u062c\\u062f\\u062f \\u062f\\u0631 \\u0646\\u0638\\u0631 \\u06af\\u0631\\u0641\\u062a\\u0647 \\u0634\\u0648\\u062f.&lt;\\\/li&gt;&lt;li&gt;\\u062a\\u0631\\u06a9\\u06cc\\u0628 \\u062a\\u0627\\u06a9\\u0633\\u0627\\u0646 \\u06cc\\u0627 \\u06a9\\u067e\\u0633\\u06cc\\u062a\\u0627\\u0628\\u06cc\\u0646 \\u0628\\u0627 \\u0628\\u0648\\u0627\\u0633\\u06cc\\u0632\\u0648\\u0645\\u0627\\u0628\\u060c \\u062f\\u0631 \\u0635\\u0648\\u0631\\u062a \\u0648\\u062c\\u0648\\u062f\\u060c \\u06af\\u0632\\u06cc\\u0646\\u0647\\u200c\\u0627\\u06cc \\u0628\\u0631\\u0627\\u06cc \\u062e\\u0637 \\u0627\\u0648\\u0644 ChT \\u0627\\u0633\\u062a.&lt;\\\/li&gt;&lt;li&gt;\\u062f\\u0631 \\u0635\\u0648\\u0631\\u062a \\u0627\\u0633\\u062a\\u0641\\u0627\\u062f\\u0647 \\u0627\\u0632 \\u06a9\\u067e\\u0633\\u06cc\\u062a\\u0627\\u0628\\u06cc\\u0646\\u060c \\u0628\\u06cc\\u0645\\u0627\\u0631\\u0627\\u0646 \\u0628\\u0627\\u06cc\\u062f \\u0642\\u0628\\u0644 \\u0627\\u0632 \\u0634\\u0631\\u0648\\u0639 \\u062f\\u0631\\u0645\\u0627\\u0646 \\u062a\\u062d\\u062a \\u0622\\u0632\\u0645\\u0627\\u06cc\\u0634 \\u0646\\u0648\\u0639 \\u0648\\u0627\\u0631\\u06cc\\u0627\\u0646\\u062a\\u200c\\u0647\\u0627\\u06cc \\u0698\\u0631\\u0645\\u06cc\\u0646\\u0627\\u0644 \\u0628\\u0631\\u0627\\u06cc \\u06a9\\u0645\\u0628\\u0648\\u062f \\u0622\\u0646\\u0632\\u06cc\\u0645 DPD \\u0642\\u0631\\u0627\\u0631 \\u06af\\u06cc\\u0631\\u0646\\u062f.&lt;\\\/li&gt;&lt;\\\/ol&gt;&lt;p&gt;ChT \\u0639\\u0645\\u0648\\u0645\\u0627\\u064b \\u0628\\u0627\\u06cc\\u062f \\u062a\\u0627 PD \\u06cc\\u0627 \\u0633\\u0645\\u06cc\\u062a \\u063a\\u06cc\\u0631\\u0642\\u0627\\u0628\\u0644 \\u062a\\u062d\\u0645\\u0644 \\u0627\\u062f\\u0627\\u0645\\u0647 \\u06cc\\u0627\\u0628\\u062f (\\u0628\\u0647 \\u0627\\u0633\\u062a\\u062b\\u0646\\u0627\\u06cc \\u0622\\u0646\\u062a\\u0631\\u0627\\u0633\\u0627\\u06cc\\u06a9\\u0644\\u06cc\\u0646 \\u0647\\u0627 \\u06a9\\u0647 \\u062f\\u0631 \\u0622\\u0646 \\u062d\\u062f \\u062a\\u062c\\u0645\\u0639\\u06cc \\u0628\\u0627\\u06cc\\u062f \\u062f\\u0631 \\u0646\\u0638\\u0631 \\u06af\\u0631\\u0641\\u062a\\u0647 \\u0634\\u0648\\u062f)&lt;\\\/p&gt;&quot;,&quot;hotspot_offset_x&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:60,&quot;sizes&quot;:[]},&quot;hotspot_offset_y&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:97,&quot;sizes&quot;:[]},&quot;hotspot_tooltip_position&quot;:&quot;yes&quot;,&quot;hotspot_position&quot;:&quot;right&quot;,&quot;hotspot_tooltip_width&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:456,&quot;sizes&quot;:[]},&quot;hotspot_tooltip_text_wrap&quot;:&quot;yes&quot;,&quot;_id&quot;:&quot;cd1eb45&quot;,&quot;hotspot_label&quot;:&quot;&quot;,&quot;hotspot_link&quot;:{&quot;url&quot;:&quot;&quot;,&quot;is_external&quot;:&quot;&quot;,&quot;nofollow&quot;:&quot;&quot;,&quot;custom_attributes&quot;:&quot;&quot;},&quot;hotspot_horizontal&quot;:&quot;right&quot;,&quot;hotspot_vertical&quot;:&quot;top&quot;,&quot;hotspot_position_tablet&quot;:&quot;&quot;,&quot;hotspot_position_mobile&quot;:&quot;&quot;,&quot;hotspot_icon_position&quot;:null,&quot;hotspot_icon_spacing&quot;:null,&quot;hotspot_width&quot;:null,&quot;hotspot_height&quot;:null,&quot;hotspot_offset_x_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;hotspot_offset_x_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;hotspot_offset_y_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;hotspot_offset_y_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;hotspot_tooltip_width_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;hotspot_tooltip_width_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}],&quot;tooltip_position&quot;:&quot;right&quot;,&quot;hotspot_sequenced_animation&quot;:&quot;no&quot;,&quot;tooltip_trigger&quot;:&quot;click&quot;,&quot;tooltip_animation&quot;:&quot;e-hotspot--fade-in-out&quot;}\" data-widget_type=\"hotspot.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/evamed.ir\/cervical-cancer\/wp-content\/uploads\/2024\/11\/fig2.jpg\" title=\"\" alt=\"\" loading=\"lazy\" \/>\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-6490865  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<ol><li>\u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u062a\u0648\u0645\u0648\u0631\u0647\u0627\u06cc\u06cc \u06a9\u0647 \u0628\u0647 \u0647\u0648\u0631\u0645\u0648\u0646\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u0645\u0642\u0627\u0648\u0645 \u0647\u0633\u062a\u0646\u062f \u0628\u0627\u06cc\u062f \u0628\u0631\u0627\u06cc \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc (ChT) \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u0646\u062f.<\/li><li>\u0628\u0647 \u0637\u0648\u0631 \u06a9\u0644\u06cc ChT \u062a\u06a9\u200c\u0639\u0627\u0645\u0644\u06cc \u0645\u062a\u0648\u0627\u0644\u06cc \u0628\u0631 \u0627\u0633\u062a\u0631\u0627\u062a\u0698\u06cc\u200c\u0647\u0627\u06cc \u062a\u0631\u06a9\u06cc\u0628\u06cc \u062a\u0631\u062c\u06cc\u062d \u062f\u0627\u062f\u0647 \u0645\u06cc \u0634\u0648\u062f. \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u0628\u0647 \u062f\u0644\u06cc\u0644 \u0646\u0627\u0631\u0633\u0627\u06cc\u06cc \u0642\u0631\u06cc\u0628 \u0627\u0644\u0648\u0642\u0648\u0639 \u0627\u0646\u062f\u0627\u0645 \u0628\u0647 \u067e\u0627\u0633\u062e \u0633\u0631\u06cc\u0639 \u0646\u06cc\u0627\u0632 \u0627\u0633\u062a\u060c ChT \u062a\u0631\u06a9\u06cc\u0628\u06cc \u062a\u0631\u062c\u06cc\u062d \u062f\u0627\u062f\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/li><li>\u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0645\u0648\u062c\u0648\u062f \u0628\u0631\u0627\u06cc ChT \u062a\u06a9 \u0639\u0627\u0645\u0644\u06cc \u0639\u0628\u0627\u0631\u062a\u0646\u062f \u0627\u0632 \u0622\u0646\u062a\u0631\u0627\u0633\u0627\u06cc\u06a9\u0644\u06cc\u0646\u200c\u0647\u0627\u060c \u062a\u0627\u06a9\u0633\u0627\u0646\u200c\u0647\u0627\u060c \u06a9\u067e\u0633\u06cc\u062a\u0627\u0628\u06cc\u0646\u060c \u0627\u0631\u06cc\u0628\u0648\u0644\u06cc\u0646\u060c \u0648\u06cc\u0646\u0648\u0631\u0644\u0628\u06cc\u0646\u060c \u067e\u0644\u0627\u062a\u06cc\u0646 \u0648 \u0633\u0627\u06cc\u0631 \u0639\u0648\u0627\u0645\u0644.<\/li><li>\u0686\u0627\u0644\u0634 \u0645\u062c\u062f\u062f \u0628\u0627 \u0622\u0646\u062a\u0631\u0627\u0633\u0627\u06cc\u06a9\u0644\u06cc\u0646\u200c\u0647\u0627 \u06cc\u0627 \u062a\u0627\u06a9\u0633\u0627\u0646\u200c\u0647\u0627 \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0628\u0627 DFI \u226512 \u0645\u0627\u0647 \u0627\u0645\u06a9\u0627\u0646\u200c\u067e\u0630\u06cc\u0631 \u0627\u0633\u062a. \u062f\u0631 \u0635\u0648\u0631\u062a \u0627\u0645\u06a9\u0627\u0646\u060c \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0622\u0646\u062a\u0631\u0627\u0633\u0627\u06cc\u06a9\u0644\u06cc\u0646\u200c\u0647\u0627\u06cc \u0644\u06cc\u067e\u0648\u0632\u0648\u0645\u06cc \u06cc\u0627 \u067e\u0627\u06a9\u0644\u06cc\u062a\u0627\u06a9\u0633\u0644 \u0645\u062a\u0635\u0644 \u0628\u0647 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0645\u0645\u06a9\u0646 \u0627\u0633\u062a \u0628\u0631\u0627\u06cc \u0686\u0627\u0644\u0634 \u0645\u062c\u062f\u062f \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f.<\/li><li>\u062a\u0631\u06a9\u06cc\u0628 \u062a\u0627\u06a9\u0633\u0627\u0646 \u06cc\u0627 \u06a9\u067e\u0633\u06cc\u062a\u0627\u0628\u06cc\u0646 \u0628\u0627 \u0628\u0648\u0627\u0633\u06cc\u0632\u0648\u0645\u0627\u0628\u060c \u062f\u0631 \u0635\u0648\u0631\u062a \u0648\u062c\u0648\u062f\u060c \u06af\u0632\u06cc\u0646\u0647\u200c\u0627\u06cc \u0628\u0631\u0627\u06cc \u062e\u0637 \u0627\u0648\u0644 ChT \u0627\u0633\u062a.<\/li><li>\u062f\u0631 \u0635\u0648\u0631\u062a \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u06a9\u067e\u0633\u06cc\u062a\u0627\u0628\u06cc\u0646\u060c \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0628\u0627\u06cc\u062f \u0642\u0628\u0644 \u0627\u0632 \u0634\u0631\u0648\u0639 \u062f\u0631\u0645\u0627\u0646 \u062a\u062d\u062a \u0622\u0632\u0645\u0627\u06cc\u0634 \u0646\u0648\u0639 \u0648\u0627\u0631\u06cc\u0627\u0646\u062a\u200c\u0647\u0627\u06cc \u0698\u0631\u0645\u06cc\u0646\u0627\u0644 \u0628\u0631\u0627\u06cc \u06a9\u0645\u0628\u0648\u062f \u0622\u0646\u0632\u06cc\u0645 DPD \u0642\u0631\u0627\u0631 \u06af\u06cc\u0631\u0646\u062f.<\/li><li>ChT \u0639\u0645\u0648\u0645\u0627\u064b \u0628\u0627\u06cc\u062f \u062a\u0627 PD \u06cc\u0627 \u0633\u0645\u06cc\u062a \u063a\u06cc\u0631\u0642\u0627\u0628\u0644 \u062a\u062d\u0645\u0644 \u0627\u062f\u0627\u0645\u0647 \u06cc\u0627\u0628\u062f (\u0628\u0647 \u0627\u0633\u062a\u062b\u0646\u0627\u06cc \u0622\u0646\u062a\u0631\u0627\u0633\u0627\u06cc\u06a9\u0644\u06cc\u0646 \u0647\u0627 \u06a9\u0647 \u062f\u0631 \u0622\u0646 \u062d\u062f \u062a\u062c\u0645\u0639\u06cc \u0628\u0627\u06cc\u062f \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f).<\/li><\/ol>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-168dd16  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<ol><li>\u06cc\u06a9 \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647 CDK4\/6 \u0647\u0645\u0631\u0627\u0647 \u0628\u0627 ET\u060c \u062f\u0631\u0645\u0627\u0646 \u062e\u0637 \u0627\u0648\u0644 \u0645\u0631\u0627\u0642\u0628\u062a\u06cc \u0627\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u062f \u0628\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u0633\u0631\u0637\u0627\u0646 \u067e\u0633\u062a\u0627\u0646 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 HER2-\u0645\u0646\u0641\u06cc \u0648 ER-\u0645\u062b\u0628\u062a \u0627\u0633\u062a\u060c \u0632\u06cc\u0631\u0627 \u0628\u0627 \u0645\u0632\u0627\u06cc\u0627\u06cc \u0642\u0627\u0628\u0644 \u062a\u0648\u062c\u0647 PFS \u0648 OS \u0647\u0645\u0631\u0627\u0647 \u0627\u0633\u062a \u0648 \u06a9\u06cc\u0641\u06cc\u062a \u0632\u0646\u062f\u06af\u06cc \u0631\u0627 \u062a\u0627 \u062d\u062f \u0632\u06cc\u0627\u062f\u06cc \u0628\u0647\u0628\u0648\u062f \u0645\u06cc\u200c\u0628\u062e\u0634\u062f.<\/li><li>\u0632\u0646\u0627\u0646 \u0642\u0628\u0644 \u0648 \u062f\u0631 \u062d\u062f\u0648\u062f \u06cc\u0627\u0626\u0633\u06af\u06cc \u0628\u0627\u06cc\u062f OFS \u0631\u0627 \u0639\u0644\u0627\u0648\u0647 \u0628\u0631 \u062a\u0645\u0627\u0645 \u062f\u0631\u0645\u0627\u0646 \u0647\u0627\u06cc \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 \u0647\u0648\u0631\u0645\u0648\u0646 \u062f\u0631\u06cc\u0627\u0641\u062a \u06a9\u0646\u0646\u062f.<\/li><\/ol><p><img decoding=\"async\" class=\"alignnone size-medium wp-image-3034\" src=\"https:\/\/evamed.ir\/cervical-cancer\/wp-content\/uploads\/2024\/12\/17-500x85.png\" alt=\"\" width=\"500\" height=\"85\" \/><\/p><p>\u00a0 \u00a0 3. \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647 \u0647\u0627\u06cc CDK4\/6 \u0686\u0647 \u062f\u0631 \u0633\u0631\u0637\u0627\u0646 \u067e\u0633\u062a\u0627\u0646 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 \u0627\u0648\u0644\u06cc\u0647 \u06cc\u0627 \u062f\u0631 \u0639\u0648\u062f \u0645\u062c\u062f\u062f\u060c \u0686\u0647 \u062f\u0631 \u0645\u0648\u0627\u0631\u062f \u0645\u0642\u0627\u0648\u0645\u062a \u0627\u0646\u062f\u0648\u06a9\u0631\u06cc\u0646 \u0627\u0648\u0644\u06cc\u0647 \u06cc\u0627 \u062b\u0627\u0646\u0648\u06cc\u0647 \u060c \u0686\u0647 \u062f\u0631 \u0632\u0646\u0627\u0646 \u06cc\u0627\u0626\u0633\u0647 \u06cc\u0627 \u0642\u0628\u0644 \u0627\u0632 \u06cc\u0627\u0626\u0633\u06af\u06cc\u060c \u0645\u0648\u062b\u0631 \u0647\u0633\u062a\u0646\u062f. \u062f\u0631 \u062d\u0627\u0644\u06cc \u06a9\u0647 \u0647\u06cc\u0686 \u0645\u0642\u0627\u06cc\u0633\u0647 \u0633\u0631 \u0628\u0647 \u0633\u0631 \u0633\u0647 \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647 CDK4\/6 \u06a9\u0647 \u062a\u0627\u06cc\u06cc\u062f \u0634\u062f\u0647 \u0628\u0627\u0634\u062f \u0648\u062c\u0648\u062f \u0646\u062f\u0627\u0631\u062f\u060c \u0627\u062b\u0631\u0628\u062e\u0634\u06cc \u0627\u06cc\u0646 \u0633\u0647 \u062f\u0627\u0631\u0648 \u062f\u0631 \u0645\u062d\u06cc\u0637 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 \u0645\u0634\u0627\u0628\u0647 \u0628\u0647 \u0646\u0638\u0631 \u0645\u06cc \u0631\u0633\u062f. \u0627\u0644\u0628\u062a\u0647 \u0645\u0634\u062e\u0635\u0627\u062a \u0633\u0645\u06cc\u062a \u0627\u06cc\u0646 \u0633\u0647 \u062f\u0627\u0631\u0648 \u06a9\u0645\u06cc \u0645\u062a\u0641\u0627\u0648\u062a \u0627\u0633\u062a \u0648 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u0633\u0645\u06cc\u062a \u0634\u062f\u06cc\u062f \u06cc\u06a9 \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647 CDK4\/6 \u0631\u0627 \u0627\u06cc\u062c\u0627\u062f \u0645\u06cc\u200c\u06a9\u0646\u0646\u062f\u060c \u0628\u0627\u06cc\u062f \u0628\u0647 \u06cc\u06a9 \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647 CDK4\/6 \u0645\u062a\u0641\u0627\u0648\u062a \u0631\u0648\u06cc \u0622\u0648\u0631\u0646\u062f.<\/p><ol><li style=\"list-style-type: none;\">\u00a0<\/li><\/ol>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-0190d61  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<ol><li>\u0627\u0646\u062a\u062e\u0627\u0628 \u062e\u0637 \u062f\u0648\u0645 \u062f\u0631\u0645\u0627\u0646 (\u0634\u06cc\u0645\u06cc \u062f\u0631\u0645\u0627\u0646\u06cc (ChT) \u062f\u0631 \u0645\u0642\u0627\u0628\u0644 \u062f\u0631\u0645\u0627\u0646 \u0627\u0646\u062f\u0648\u06a9\u0631\u06cc\u0646) \u0628\u0627\u06cc\u062f \u0628\u0631 \u0627\u0633\u0627\u0633 \u0634\u062f\u062a\u060c \u0648\u0633\u0639\u062a \u0648 \u0639\u0645\u0644\u06a9\u0631\u062f \u0627\u0646\u062f\u0627\u0645 \u0628\u0627\u0634\u062f \u0648 \u0645\u0634\u062e\u0635\u0627\u062a \u0633\u0645\u06cc\u062a \u0645\u0631\u062a\u0628\u0637 \u0631\u0627 \u062f\u0631 \u0646\u0638\u0631 \u0628\u06af\u06cc\u0631\u062f.<\/li><li>\u062d\u062f\u0627\u0642\u0644 \u062f\u0648 \u062e\u0637 \u0647\u0648\u0631\u0645\u0648\u0646\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u0642\u0628\u0644 \u0627\u0632 \u0627\u0646\u062a\u0642\u0627\u0644 \u0628\u0647 ChT \u062a\u0631\u062c\u06cc\u062d \u062f\u0627\u062f\u0647 \u0645\u06cc \u0634\u0648\u062f.<\/li><li>\u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u0646\u0627\u0631\u0633\u0627\u06cc\u06cc \u0642\u0631\u06cc\u0628 \u0627\u0644\u0648\u0642\u0648\u0639 \u0627\u0631\u06af\u0627\u0646\u060c ChT \u06cc\u06a9 \u06af\u0632\u06cc\u0646\u0647 \u0627\u0631\u062c\u062d \u0627\u0633\u062a.<\/li><li style=\"list-style-type: none;\">\u00a0<\/li><\/ol>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-d52dce7  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<ol><li>\u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u067e\u0633 \u0627\u0632 ET \u0628\u0647 \u0627\u0636\u0627\u0641\u0647 \u06cc\u06a9 \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647 CDK4\/6 \u062f\u0686\u0627\u0631 \u0639\u0648\u062f \u0645\u062c\u062f\u062f \u0645\u06cc\u200c\u0634\u0648\u0646\u062f\u060c \u062a\u0639\u06cc\u06cc\u0646 \u062c\u0647\u0634\u200c\u0647\u0627\u06cc \u0633\u0648\u0645\u0627\u062a\u06cc\u06a9 PIK3CA \u0648 \u06af\u06cc\u0631\u0646\u062f\u0647 \u0627\u0633\u062a\u0631\u0648\u0698\u0646 1 (ESR1) \u0648 \u0647\u0645\u0686\u0646\u06cc\u0646 \u062c\u0647\u0634\u200c\u0647\u0627\u06cc \u0698\u0631\u0645\u06cc\u0646\u0627\u0644 BRCA1\/2 \u0648 PALB2\u060c \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/li><\/ol>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-7f30beb  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<ol><li>\u0645\u0648\u0646\u0648\u200c\u062a\u0631\u0627\u067e\u06cc \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647 PARP (\u0627\u0648\u0644\u0627\u067e\u0627\u0631\u06cc\u0628 \u06cc\u0627 \u062a\u0627\u0644\u0627\u0632\u0648\u067e\u0627\u0631\u06cc\u0628) \u0628\u0627\u06cc\u062f \u0628\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u062c\u0647\u0634\u200c\u0647\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc\u200c\u0632\u0627\u06cc \u0698\u0631\u0645\u06cc\u0646\u0627\u0644 BRCA1\/2 \u0648 \u0628\u0647\u200c\u0639\u0646\u0648\u0627\u0646 \u06af\u0632\u06cc\u0646\u0647\u200c\u0627\u06cc \u0628\u0631\u0627\u06cc \u06a9\u0633\u0627\u0646\u06cc \u06a9\u0647 \u062f\u0627\u0631\u0627\u06cc \u062c\u0647\u0634\u200c\u0647\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc\u200c\u0632\u0627\u06cc \u0633\u0648\u0645\u0627\u062a\u06cc\u06a9 \u06cc\u0627 \u0627\u062d\u062a\u0645\u0627\u0644\u0627\u064b \u0628\u06cc\u0645\u0627\u0631\u06cc\u200c\u0632\u0627\u06cc BRCA1\/2 \u06cc\u0627 PALB2 \u0647\u0633\u062a\u0646\u062f\u060c \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f.\u00a0<\/li><\/ol><p>\u00a0 \u00a0 \u00a0 \u00a0 <img decoding=\"async\" class=\"alignnone size-full wp-image-3047\" src=\"https:\/\/evamed.ir\/cervical-cancer\/wp-content\/uploads\/2024\/12\/28.png\" alt=\"\" width=\"460\" height=\"79\" \/><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-d3ed36e  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<ol><li>Alpelisib-fulvestrant \u06cc\u06a9 \u06af\u0632\u06cc\u0646\u0647 \u062f\u0631\u0645\u0627\u0646\u06cc \u0628\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u062a\u0648\u0645\u0648\u0631\u0647\u0627\u06cc \u062c\u0647\u0634 \u06cc\u0627\u0641\u062a\u0647 PIK3CA (\u062f\u0631 \u0627\u06af\u0632\u0648\u0646 \u0647\u0627\u06cc 7\u060c 9 \u06cc\u0627 20) \u060c \u0628\u0627 \u0633\u0637\u0648\u062d \u0645\u0646\u0627\u0633\u0628 HbA1c \u0627\u0633\u062a. \u0627\u06cc\u0646 \u062f\u0631\u0645\u0627\u0646 \u0642\u0628\u0644 \u0627\u0632 \u0645\u0648\u0627\u062c\u0647\u0647 \u0628\u0627 \u06cc\u06a9 \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647\u200c\u06cc \u0622\u0631\u0648\u0645\u0627\u062a\u0627\u0632 (\u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647 \u00b1 CDK4\/6) \u0627\u0646\u062c\u0627\u0645 \u0645\u06cc<u>\u200c<\/u>\u0634\u0648\u062f.<img decoding=\"async\" class=\"alignnone size-medium wp-image-3045\" src=\"https:\/\/evamed.ir\/cervical-cancer\/wp-content\/uploads\/2024\/12\/26-500x46.png\" alt=\"\" width=\"500\" height=\"46\" \/><\/li><\/ol><p><strong>\u00a0 \u00a0Elacestrant<\/strong><\/p><p>2.\u00a0 \u06cc\u06a9 \u06af\u0632\u06cc\u0646\u0647 \u0628\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u0633\u0631\u0637\u0627\u0646 \u067e\u0633\u062a\u0627\u0646 \u0628\u0627 ER \u0645\u062b\u0628\u062a\u060c HER2 \u0645\u0646\u0641\u06cc \u0648 ESR1 \u062c\u0647\u0634\u200c\u06cc\u0627\u0641\u062a\u0647 \u0627\u0633\u062a \u06a9\u0647 \u067e\u0633 \u0627\u0632 \u062d\u062f\u0627\u0642\u0644 \u06cc\u06a9 \u062e\u0637 \u062f\u0631\u0645\u0627\u0646 \u0627\u0646\u062f\u0648\u06a9\u0631\u06cc\u0646 \u062f\u0631 \u062d\u0627\u0644 \u067e\u06cc\u0634\u0631\u0641\u062a \u0645\u06cc\u200c\u0628\u0627\u0634\u062f.\u00a0 <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3046\" src=\"https:\/\/evamed.ir\/cervical-cancer\/wp-content\/uploads\/2024\/12\/27.png\" alt=\"\" width=\"458\" height=\"52\" \/><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-1ab77e3  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<ol><li>exemestane \u06cc\u06a9 \u06af\u0632\u06cc\u0646\u0647 \u0628\u0633\u06cc\u0627\u0631 \u062c\u062f\u06cc \u0627\u0633\u062a \u0632\u06cc\u0631\u0627 PFS \u0631\u0627 \u0628\u0647 \u0645\u06cc\u0632\u0627\u0646 \u0642\u0627\u0628\u0644 \u062a\u0648\u062c\u0647\u06cc \u0637\u0648\u0644\u0627\u0646\u06cc \u0645\u06cc\u200c\u06a9\u0646\u062f. \u062a\u0627\u0645\u0648\u06a9\u0633\u06cc\u0641\u0646 \u06cc\u0627 \u0641\u0648\u0644\u0648\u0633\u062a\u0631\u0627\u0646\u062a \u0631\u0627 \u0646\u06cc\u0632 \u0645\u06cc \u062a\u0648\u0627\u0646 \u0628\u0627 \u0627\u0648\u0631\u0648\u0644\u06cc\u0645\u0648\u0633 \u062a\u0631\u06a9\u06cc\u0628 \u06a9\u0631\u062f. \u062f\u0631 \u0635\u0648\u0631\u062a \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0627\u0648\u0631\u0648\u0644\u06cc\u0645\u0648\u0633\u060c \u0628\u0627\u06cc\u062f \u0627\u0632 \u067e\u0631\u0648\u0641\u06cc\u0644\u0627\u06a9\u0633\u06cc \u0627\u0633\u062a\u0648\u0645\u0627\u062a\u06cc\u062a \u0628\u0627 \u062f\u0647\u0627\u0646\u200c\u0634\u0648\u06cc\u0647 \u0627\u0633\u062a\u0631\u0648\u0626\u06cc\u062f\u06cc \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0634\u0648\u062f.<\/li><li>\u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u062a\u0648\u0645\u0648\u0631\u0647\u0627\u06cc \u062d\u0627\u0648\u06cc \u062c\u0647\u0634 ESR1\u060c \u062c\u0627\u06cc\u06af\u0632\u06cc\u0646\u06cc \u0627\u06af\u0632\u0645\u0633\u062a\u0627\u0646 \u0628\u0627 \u0641\u0648\u0644\u0648\u0633\u062a\u0631\u0627\u0646\u062a \u062a\u0631\u062c\u06cc\u062d \u062f\u0627\u062f\u0647 \u0645\u06cc \u0634\u0648\u062f.<\/li><\/ol><p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-3036\" src=\"https:\/\/evamed.ir\/cervical-cancer\/wp-content\/uploads\/2024\/12\/25-500x46.png\" alt=\"\" width=\"500\" height=\"46\" \/><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-643d0cf  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<ol><li>\u0628\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u062a\u0648\u0645\u0648\u0631\u0647\u0627\u06cc \u062d\u0633\u0627\u0633 \u0628\u0647 \u062f\u0631\u0645\u0627\u0646 \u0627\u0646\u062f\u0648\u06a9\u0631\u06cc\u0646\u060c \u0627\u062f\u0627\u0645\u0647 ET \u0628\u0627 \u062f\u0627\u0631\u0648\u0647\u0627\u06cc\u06cc \u06a9\u0647 \u0642\u0628\u0644\u0627\u064b \u062f\u0631 \u0634\u0631\u0627\u06cc\u0637 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 \u062f\u0631\u06cc\u0627\u0641\u062a \u0646\u0634\u062f\u0647\u200c\u0627\u0646\u062f \u0645\u0645\u06a9\u0646 \u0627\u0633\u062a \u06cc\u06a9 \u06af\u0632\u06cc\u0646\u0647 \u0628\u0627\u0634\u062f.<\/li><li>\u0645\u0644\u0627\u062d\u0638\u0627\u062a \u0645\u0631\u0628\u0648\u0637 \u0628\u0647 \u062f\u0631\u0645\u0627\u0646 \u062f\u0631 \u062e\u0637 \u0633\u0648\u0645 \u0648 \u0641\u0631\u0627\u062a\u0631 \u0627\u0632 \u0622\u0646 \u0628\u0627\u06cc\u062f \u062d\u0633\u0627\u0633\u06cc\u062a \u0628\u0647 \u062f\u0631\u0645\u0627\u0646 \u0647\u0627\u06cc \u0642\u0628\u0644\u06cc \u062f\u0631\u06cc\u0627\u0641\u062a\u06cc\u060c \u0632\u0645\u0627\u0646 \u067e\u06cc\u0634\u0631\u0641\u062a\u060c \u0648\u0636\u0639\u06cc\u062a gBRCAm\u060c \u0628\u06cc\u0648\u0644\u0648\u0698\u06cc \u062a\u0648\u0645\u0648\u0631 (\u0627\u0632 \u062c\u0645\u0644\u0647 \u0633\u0627\u06cc\u0631 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0698\u0631\u0645\u06cc\u0646\u0627\u0644 \u0648 \u0633\u0648\u0645\u0627\u062a\u06cc\u06a9\u060c \u062f\u0631 \u0635\u0648\u0631\u062a \u062f\u0631 \u062f\u0633\u062a\u0631\u0633 \u0628\u0648\u062f\u0646 \u0646\u062a\u0627\u06cc\u062c) \u0648 \u0645\u06a9\u0627\u0646\u06cc\u0633\u0645 \u0647\u0627\u06cc \u0645\u0642\u0627\u0648\u0645\u062a\u06cc \u06a9\u0647 \u0645\u0645\u06a9\u0646 \u0627\u0633\u062a \u062f\u0631 \u0637\u0648\u0644 \u062f\u0631\u0645\u0627\u0646\u200c\u0647\u0627\u06cc \u0642\u0628\u0644\u06cc \u0627\u06cc\u062c\u0627\u062f \u0634\u062f\u0647 \u0628\u0627\u0634\u0646\u062f \u0631\u0627 \u062f\u0631 \u0646\u0638\u0631 \u0628\u06af\u06cc\u0631\u062f (\u062f\u0631 \u0635\u0648\u0631\u062a \u0627\u0645\u06a9\u0627\u0646\u060c \u0628\u06cc\u0648\u067e\u0633\u06cc \u062a\u0648\u0645\u0648\u0631 \u06cc\u0627 \u062a\u062c\u0632\u06cc\u0647 \u0648 \u062a\u062d\u0644\u06cc\u0644 ctDNA \u0645\u0645\u06a9\u0646 \u0627\u0633\u062a \u0627\u0646\u062c\u0627\u0645 \u0634\u0648\u062f).<\/li><\/ol>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-cd1eb45  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__tooltip  e-hotspot--tooltip-position e-hotspot--fade-in-out \" >\n\t\t\t\t\t\t<ol><li>Sacituzumab Govitecan \u0628\u0627\u06cc\u062f \u0628\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u0633\u0631\u0637\u0627\u0646 \u067e\u0633\u062a\u0627\u0646 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 HR-\u0645\u062b\u0628\u062a \u0648 HER2-0 \u067e\u0633 \u0627\u0632 \u062d\u062f\u0627\u0642\u0644 \u062f\u0648 \u062e\u0637 ChT \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f.<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-3048\" src=\"https:\/\/evamed.ir\/cervical-cancer\/wp-content\/uploads\/2024\/12\/31-500x39.png\" alt=\"\" width=\"500\" height=\"39\" \/><\/li><\/ol><p><strong>Trastuzumab Deruxtecan for HER2-low<\/strong><\/p><ol start=\"2\"><li>Trastuzumab deruxtecan \u0628\u0627\u06cc\u062f \u0628\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u0633\u0631\u0637\u0627\u0646 \u067e\u0633\u062a\u0627\u0646 \u0645\u062a\u0627\u0633\u062a\u0627\u062a\u06cc\u06a9 HER2-low \u067e\u0633 \u0627\u0632 \u062d\u062f\u0627\u0642\u0644 \u06cc\u06a9 \u062e\u0637 ChT \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f.<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-3049\" src=\"https:\/\/evamed.ir\/cervical-cancer\/wp-content\/uploads\/2024\/12\/32-500x50.png\" alt=\"\" width=\"500\" height=\"50\" \/><\/li><\/ol><p><strong>Chemotherapy<\/strong><\/p><ol start=\"3\"><li>\u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u062a\u0648\u0645\u0648\u0631\u0647\u0627\u06cc\u06cc \u06a9\u0647 \u0628\u0647 \u0647\u0648\u0631\u0645\u0648\u0646\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u0645\u0642\u0627\u0648\u0645 \u0647\u0633\u062a\u0646\u062f \u0628\u0627\u06cc\u062f \u0628\u0631\u0627\u06cc ChT \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u0646\u062f.<\/li><li>\u0628\u0647 \u0637\u0648\u0631 \u06a9\u0644\u06cc ChT \u062a\u06a9\u200c\u0639\u0627\u0645\u0644\u06cc \u0645\u062a\u0648\u0627\u0644\u06cc \u0628\u0631 \u0627\u0633\u062a\u0631\u0627\u062a\u0698\u06cc\u200c\u0647\u0627\u06cc \u062a\u0631\u06a9\u06cc\u0628\u06cc \u062a\u0631\u062c\u06cc\u062d \u062f\u0627\u062f\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f. \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u0628\u0647 \u062f\u0644\u06cc\u0644 \u0646\u0627\u0631\u0633\u0627\u06cc\u06cc \u0642\u0631\u06cc\u0628 \u0627\u0644\u0648\u0642\u0648\u0639 \u0627\u0646\u062f\u0627\u0645 \u0628\u0647 \u067e\u0627\u0633\u062e \u0633\u0631\u06cc\u0639 \u0646\u06cc\u0627\u0632 \u0627\u0633\u062a\u060c ChT \u062a\u0631\u06a9\u06cc\u0628\u06cc \u062a\u0631\u062c\u06cc\u062d \u062f\u0627\u062f\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/li><li>\u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0645\u0648\u062c\u0648\u062f \u0628\u0631\u0627\u06cc ChT \u062a\u06a9 \u0639\u0627\u0645\u0644\u06cc \u0639\u0628\u0627\u0631\u062a\u0646\u062f \u0627\u0632 \u0622\u0646\u062a\u0631\u0627\u0633\u0627\u06cc\u06a9\u0644\u06cc\u0646\u200c\u0647\u0627\u060c \u062a\u0627\u06a9\u0633\u0627\u0646\u200c\u0647\u0627\u060c \u06a9\u067e\u0633\u06cc\u062a\u0627\u0628\u06cc\u0646\u060c \u0627\u0631\u06cc\u0628\u0648\u0644\u06cc\u0646\u060c \u0648\u06cc\u0646\u0648\u0631\u0644\u0628\u06cc\u0646\u060c \u067e\u0644\u0627\u062a\u06cc\u0646 \u0648 \u0633\u0627\u06cc\u0631 \u0639\u0648\u0627\u0645\u0644.<\/li><li>\u0686\u0627\u0644\u0634 \u0645\u062c\u062f\u062f \u0628\u0627 \u0622\u0646\u062a\u0631\u0627\u0633\u0627\u06cc\u06a9\u0644\u06cc\u0646\u200c\u0647\u0627 \u06cc\u0627 \u062a\u0627\u06a9\u0633\u0627\u0646\u200c\u0647\u0627 \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0628\u0627 DFI \u226512 \u0645\u0627\u0647 \u0627\u0645\u06a9\u0627\u0646\u200c\u067e\u0630\u06cc\u0631 \u0627\u0633\u062a. \u062f\u0631 \u0635\u0648\u0631\u062a \u0627\u0645\u06a9\u0627\u0646\u060c \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0622\u0646\u062a\u0631\u0627\u0633\u0627\u06cc\u06a9\u0644\u06cc\u0646\u200c\u0647\u0627\u06cc \u0644\u06cc\u067e\u0648\u0632\u0648\u0645\u06cc \u06cc\u0627 \u067e\u0627\u06a9\u0644\u06cc\u062a\u0627\u06a9\u0633\u0644 \u0645\u062a\u0635\u0644 \u0628\u0647 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0645\u0645\u06a9\u0646 \u0627\u0633\u062a \u0628\u0631\u0627\u06cc \u0686\u0627\u0644\u0634 \u0645\u062c\u062f\u062f \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f.<\/li><li>\u062a\u0631\u06a9\u06cc\u0628 \u062a\u0627\u06a9\u0633\u0627\u0646 \u06cc\u0627 \u06a9\u067e\u0633\u06cc\u062a\u0627\u0628\u06cc\u0646 \u0628\u0627 \u0628\u0648\u0627\u0633\u06cc\u0632\u0648\u0645\u0627\u0628\u060c \u062f\u0631 \u0635\u0648\u0631\u062a \u0648\u062c\u0648\u062f\u060c \u06af\u0632\u06cc\u0646\u0647\u200c\u0627\u06cc \u0628\u0631\u0627\u06cc \u062e\u0637 \u0627\u0648\u0644 ChT \u0627\u0633\u062a.<\/li><li>\u062f\u0631 \u0635\u0648\u0631\u062a \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u06a9\u067e\u0633\u06cc\u062a\u0627\u0628\u06cc\u0646\u060c \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0628\u0627\u06cc\u062f \u0642\u0628\u0644 \u0627\u0632 \u0634\u0631\u0648\u0639 \u062f\u0631\u0645\u0627\u0646 \u062a\u062d\u062a \u0622\u0632\u0645\u0627\u06cc\u0634 \u0646\u0648\u0639 \u0648\u0627\u0631\u06cc\u0627\u0646\u062a\u200c\u0647\u0627\u06cc \u0698\u0631\u0645\u06cc\u0646\u0627\u0644 \u0628\u0631\u0627\u06cc \u06a9\u0645\u0628\u0648\u062f \u0622\u0646\u0632\u06cc\u0645 DPD \u0642\u0631\u0627\u0631 \u06af\u06cc\u0631\u0646\u062f.<\/li><\/ol><p>ChT \u0639\u0645\u0648\u0645\u0627\u064b \u0628\u0627\u06cc\u062f \u062a\u0627 PD \u06cc\u0627 \u0633\u0645\u06cc\u062a \u063a\u06cc\u0631\u0642\u0627\u0628\u0644 \u062a\u062d\u0645\u0644 \u0627\u062f\u0627\u0645\u0647 \u06cc\u0627\u0628\u062f (\u0628\u0647 \u0627\u0633\u062a\u062b\u0646\u0627\u06cc \u0622\u0646\u062a\u0631\u0627\u0633\u0627\u06cc\u06a9\u0644\u06cc\u0646 \u0647\u0627 \u06a9\u0647 \u062f\u0631 \u0622\u0646 \u062d\u062f \u062a\u062c\u0645\u0639\u06cc \u0628\u0627\u06cc\u062f \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u062f)<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3b8b884 e-con-full e-flex e-con e-child\" data-id=\"3b8b884\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4cff34a elementor-widget elementor-widget-spacer\" data-id=\"4cff34a\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d2ddce1 e-flex e-con-boxed e-con e-parent\" data-id=\"d2ddce1\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-89cfb9f elementor-widget elementor-widget-spacer\" data-id=\"89cfb9f\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-42e7663 e-flex e-con-boxed e-con e-parent\" data-id=\"42e7663\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0436d20 e-con-full e-flex e-con e-child\" data-id=\"0436d20\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1dd4a4b e-con-full e-flex e-con e-child\" data-id=\"1dd4a4b\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-87412a4 elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"87412a4\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-817e82b elementor-widget elementor-widget-text-editor\" data-id=\"817e82b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: left;\">AI, aromatase inhibitor; CDK4\/6, cyclin-dependent kinase 4 and 6; ChT, chemotherapy; EMA, European Medicines Agency; ER, estrogen receptor; ESCAT, ESMO Scale for Clinical Actionability of Molecular Targets;\u00a0<em>ESR1<\/em>,\u00a0<em>estrogen receptor 1<\/em>; ET, endocrine therapy; FDA, Food and Drug Administration; HER2, human epidermal growth factor receptor 2; m, mutation; MBC, metastatic breast cancer; MCBS, ESMO-Magnitude of Clinical Benefit Scale; OFS, ovarian function suppression;\u00a0<em>PALB2<\/em>,\u00a0<em>partner and localiser of BRCA2<\/em>; PARP, poly (ADP-ribose) polymerase; PD, progressive disease; PFS, progression-free survival;\u00a0<em>PIK3CA<\/em>,\u00a0<em>phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha<\/em>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-643d9ef e-con-full e-flex e-con e-child\" data-id=\"643d9ef\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u062a\u0648\u0645\u0648\u0631\u0647\u0627\u06cc\u06cc \u06a9\u0647 \u0628\u0647 \u0647\u0648\u0631\u0645\u0648\u0646\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u0645\u0642\u0627\u0648\u0645 \u0647\u0633\u062a\u0646\u062f \u0628\u0627\u06cc\u062f \u0628\u0631\u0627\u06cc \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc (ChT) \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u0648\u0646\u062f. \u0628\u0647 \u0637\u0648\u0631 \u06a9\u0644\u06cc ChT \u062a\u06a9\u200c\u0639\u0627\u0645\u0644\u06cc \u0645\u062a\u0648\u0627\u0644\u06cc \u0628\u0631 \u0627\u0633\u062a\u0631\u0627\u062a\u0698\u06cc\u200c\u0647\u0627\u06cc \u062a\u0631\u06a9\u06cc\u0628\u06cc \u062a\u0631\u062c\u06cc\u062d \u062f\u0627\u062f\u0647 \u0645\u06cc \u0634\u0648\u062f. \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u0628\u0647 \u062f\u0644\u06cc\u0644 \u0646\u0627\u0631\u0633\u0627\u06cc\u06cc \u0642\u0631\u06cc\u0628 \u0627\u0644\u0648\u0642\u0648\u0639 \u0627\u0646\u062f\u0627\u0645 \u0628\u0647 \u067e\u0627\u0633\u062e \u0633\u0631\u06cc\u0639 \u0646\u06cc\u0627\u0632 \u0627\u0633\u062a\u060c ChT \u062a\u0631\u06a9\u06cc\u0628\u06cc \u062a\u0631\u062c\u06cc\u062d \u062f\u0627\u062f\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f. \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0645\u0648\u062c\u0648\u062f \u0628\u0631\u0627\u06cc ChT \u062a\u06a9 \u0639\u0627\u0645\u0644\u06cc 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