{"id":3574,"date":"2024-12-18T00:31:42","date_gmt":"2024-12-17T21:01:42","guid":{"rendered":"https:\/\/evamed.ir\/cervical-cancer\/?p=3574"},"modified":"2024-12-18T00:35:16","modified_gmt":"2024-12-17T21:05:16","slug":"risk-reduction-and-screening-of-cance","status":"publish","type":"post","link":"https:\/\/evamed.ir\/cervical-cancer\/risk-reduction-and-screening-of-cance\/","title":{"rendered":"Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO Clinical Practice Guideline"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3574\" class=\"elementor elementor-3574\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ec2946 e-flex e-con-boxed e-con e-parent\" data-id=\"9ec2946\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dc7db21 elementor-widget elementor-widget-spacer\" data-id=\"dc7db21\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a468e88 e-flex e-con-boxed e-con e-parent\" data-id=\"a468e88\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-985f5e4 e-con-full e-flex e-con e-child\" data-id=\"985f5e4\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-76708e9 e-con-full e-flex e-con e-child\" data-id=\"76708e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3446fbb elementor-widget elementor-widget-heading\" data-id=\"3446fbb\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Risk reduction and screening of cancer in hereditary breast-ovarian cancer\nsyndromes: ESMO Clinical Practice Guideline<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-381f928 elementor-widget elementor-widget-text-editor\" data-id=\"381f928\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: left;\"><span class=\"fontstyle0\">Hereditary breast and ovarian cancer syndrome (HBOC) is clinically de<\/span><span class=\"fontstyle2\">fi<\/span><span class=\"fontstyle0\">ned by family history criteria, and molecularly de<\/span><span class=\"fontstyle2\">fi<\/span><span class=\"fontstyle0\">ned by identi<\/span><span class=\"fontstyle2\">fi<\/span><span class=\"fontstyle0\">cation of germline pathogenic variants (PVs) in clinically validated HBOC genes.<\/span><span class=\"fontstyle0\">1 <\/span><span class=\"fontstyle0\">These genes are broadly classi<\/span><span class=\"fontstyle2\">fi<\/span><span class=\"fontstyle0\">ed as high-risk genes, increasing breast and or tubo-ovarian cancer risk by at least fourfold, and moderate-risk genes, increasing risk by two- to fourfold <\/span><span class=\"fontstyle0\">\u00a0There is a large overlap between clinical and molecular HBOC, i.e. individuals with both family history and a PV. The genetic basis of about half of clinical HBOC, however, is currently unknown or unexplained by singlegene variants,<\/span><span class=\"fontstyle0\">2 <\/span><span class=\"fontstyle0\">and conversely, approximately half of individuals who harbour PVs in HBOC genes do not have a suggestive family history<\/span><span class=\"fontstyle0\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-63cf7af e-con-full e-flex e-con e-child\" data-id=\"63cf7af\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4bf1600 elementor-widget elementor-widget-image\" data-id=\"4bf1600\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"565\" height=\"763\" src=\"https:\/\/evamed.ir\/cervical-cancer\/wp-content\/uploads\/2024\/12\/esmo2.jpg\" class=\"attachment-large size-large wp-image-3576\" alt=\"\" srcset=\"https:\/\/evamed.ir\/cervical-cancer\/wp-content\/uploads\/2024\/12\/esmo2.jpg 565w, https:\/\/evamed.ir\/cervical-cancer\/wp-content\/uploads\/2024\/12\/esmo2-370x500.jpg 370w, https:\/\/evamed.ir\/cervical-cancer\/wp-content\/uploads\/2024\/12\/esmo2-222x300.jpg 222w\" sizes=\"(max-width: 565px) 100vw, 565px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d7f9baa elementor-align-center elementor-widget elementor-widget-button\" data-id=\"d7f9baa\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/evamed.ir\/cervical-cancer\/wp-content\/uploads\/2024\/12\/PIIS092375342204193X.pdf\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">download<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO Clinical Practice Guideline Hereditary breast and ovarian cancer syndrome (HBOC) is clinically defined by family history criteria, and molecularly defined by identification of germline pathogenic variants (PVs) in clinically validated HBOC genes.1 These genes are broadly classified as high-risk genes, increasing breast and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[],"class_list":["post-3574","post","type-post","status-publish","format-standard","hentry","category-articles"],"_links":{"self":[{"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/posts\/3574","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/comments?post=3574"}],"version-history":[{"count":5,"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/posts\/3574\/revisions"}],"predecessor-version":[{"id":3606,"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/posts\/3574\/revisions\/3606"}],"wp:attachment":[{"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/media?parent=3574"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/categories?post=3574"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/evamed.ir\/cervical-cancer\/wp-json\/wp\/v2\/tags?post=3574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}