{"id":4392,"date":"2025-09-08T08:48:14","date_gmt":"2025-09-08T05:18:14","guid":{"rendered":"https:\/\/evamed.ir\/ovarian-cancer\/?p=4392"},"modified":"2025-09-08T09:23:02","modified_gmt":"2025-09-08T05:53:02","slug":"pathology-and-molecular-biology-of-eoc-subtypes","status":"publish","type":"post","link":"https:\/\/evamed.ir\/ovarian-cancer\/pathology-and-molecular-biology-of-eoc-subtypes\/","title":{"rendered":"Pathology and molecular biology of EOC subtypes"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"4392\" class=\"elementor elementor-4392\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a99033f e-flex e-con-boxed e-con e-parent\" data-id=\"a99033f\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-379c8b1 e-con-full e-flex e-con e-child\" data-id=\"379c8b1\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b7e4e25 e-con-full e-flex e-con e-child\" data-id=\"b7e4e25\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cf46c49 elementor-widget elementor-widget-hotspot\" data-id=\"cf46c49\" data-element_type=\"widget\" data-settings=\"{&quot;hotspot&quot;:[{&quot;hotspot_icon&quot;:{&quot;value&quot;:&quot;fas 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data-widget_type=\"hotspot.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"300\" src=\"https:\/\/evamed.ir\/ovarian-cancer\/wp-content\/uploads\/2025\/09\/tab-2.png\" class=\"attachment-large size-large wp-image-4383\" alt=\"\" srcset=\"https:\/\/evamed.ir\/ovarian-cancer\/wp-content\/uploads\/2025\/09\/tab-2.png 1187w, https:\/\/evamed.ir\/ovarian-cancer\/wp-content\/uploads\/2025\/09\/tab-2-500x187.png 500w, https:\/\/evamed.ir\/ovarian-cancer\/wp-content\/uploads\/2025\/09\/tab-2-300x112.png 300w, https:\/\/evamed.ir\/ovarian-cancer\/wp-content\/uploads\/2025\/09\/tab-2-768x288.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\n\t\t\t\t\t\t<div class=\"e-hotspot elementor-repeater-item-d52dce7  e-hotspot--position-right e-hotspot--position-top   e-hotspot--icon\">\n\n\t\t\t\t\t\t\t\t<div class=\"e-hotspot__button e-hotspot--soft-beat\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"e-hotspot__icon\"><svg class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\n\t\t\t<\/div>\n\n\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b76f119 e-con-full e-flex e-con e-child\" data-id=\"b76f119\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c39cf54 e-flex e-con-boxed e-con e-parent\" data-id=\"c39cf54\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e2db2fb e-con-full e-flex e-con e-child\" data-id=\"e2db2fb\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e83cd59 e-con-full e-flex e-con e-child\" data-id=\"e83cd59\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7dcfaee elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"7dcfaee\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-info-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c5c62ca elementor-widget elementor-widget-text-editor\" data-id=\"c5c62ca\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><b>\u062a\u0648\u0636\u06cc\u062d\u0627\u062a \u062c\u062f\u0648\u0644<\/b><\/h3><h4><b>1. <\/b><b>\u0632\u06cc\u0631\u06af\u0648\u0646\u0647\u200c\u0647\u0627:<\/b><\/h4><p>.1HGSC: \u0633\u0631\u0637\u0627\u0646 \u0633\u0631\u0648\u0632\u06cc \u0628\u0627 \u062f\u0631\u062c\u0647 \u0628\u0627\u0644\u0627<\/p><p>.2EC: \u0633\u0631\u0637\u0627\u0646 \u0627\u0646\u062f\u0648\u0645\u062a\u0631\u06cc\u0648\u0626\u06cc\u062f<\/p><p>.3CC: \u0633\u0631\u0637\u0627\u0646 \u0633\u0644\u0648\u0644\u200c\u0647\u0627\u06cc \u0634\u0641\u0627\u0641<\/p><p>.4LGSC: \u0633\u0631\u0637\u0627\u0646 \u0633\u0631\u0648\u0632\u06cc \u0628\u0627 \u062f\u0631\u062c\u0647 \u067e\u0627\u06cc\u06cc\u0646<\/p><p>.5MC: \u0633\u0631\u0637\u0627\u0646 \u0645\u0648\u0633\u06cc\u0646\u0648\u0633<\/p><h4><b>2. <\/b><b>IHC Staining <\/b><b>(\u0631\u0646\u06af\u200c\u0622\u0645\u06cc\u0632\u06cc \u0627\u06cc\u0645\u0646\u0648\u0647\u06cc\u0633\u062a\u0648\u0634\u06cc\u0645\u06cc):<\/b><\/h4><p>\u0646\u0634\u0627\u0646\u200c\u062f\u0647\u0646\u062f\u0647 \u0628\u06cc\u0627\u0646 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646\u200c\u0647\u0627\u06cc \u06a9\u0644\u06cc\u062f\u06cc \u0627\u0633\u062a. \u0639\u0644\u0627\u0645\u062a \u201c+\u201d \u06cc\u0639\u0646\u06cc \u0628\u06cc\u0627\u0646 \u0645\u062b\u0628\u062a\u060c \u201c-\u201d \u06cc\u0639\u0646\u06cc \u0645\u0646\u0641\u06cc\u060c \u0648 \u201c+\/-\u201d \u06cc\u0639\u0646\u06cc \u0645\u062a\u063a\u06cc\u0631 \u06cc\u0627 \u0646\u0627\u0642\u0635.<\/p><h4><b>3. <\/b><b>\u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc:<\/b><\/h4><p>.1\u0633\u062a\u0648\u0646 \u00a0Molecular alterations \u0646\u0634\u0627\u0646\u200c\u062f\u0647\u0646\u062f\u0647 \u0698\u0646\u200c\u0647\u0627 \u0648 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0631\u0627\u06cc\u062c \u062f\u0631 \u0647\u0631 \u0632\u06cc\u0631\u06af\u0648\u0646\u0647 \u0627\u0633\u062a.<\/p><p>.2\u0627\u06cc\u0646 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0627\u0632 \u0628\u0627\u0644\u0627 \u0628\u0647 \u067e\u0627\u06cc\u06cc\u0646 \u0627\u0632 \u0634\u0627\u06cc\u0639\u200c\u062a\u0631\u06cc\u0646 \u0628\u0647 <b>\u0646\u0627\u062f\u0631\u062a\u0631\u06cc\u0646<\/b> \u0645\u0631\u062a\u0628 \u0634\u062f\u0647\u200c\u0627\u0646\u062f.<\/p><h4><b>4. \u0648\u06cc\u0698\u06af\u06cc\u200c\u0647\u0627\u06cc \u06a9\u0644\u06cc\u062f\u06cc:<\/b><\/h4><p>.1HGSC: \u0627\u063a\u0644\u0628 \u062c\u0647\u0634 TP53 \u0648 BRCA1\/2 \u00a0\u062f\u0627\u0631\u062f.<\/p><p>.2EC: \u0627\u063a\u0644\u0628 \u00a0CTNNB \u0648 \u00a0ARID1A \u0631\u0627 \u0646\u0634\u0627\u0646 \u0645\u06cc\u200c\u062f\u0647\u062f \u0648 \u062f\u0631 \u0645\u0648\u0627\u0631\u062f \u062f\u0631\u062c\u0647 \u0628\u0627\u0644\u0627 \u00a0TP53 \u0646\u06cc\u0632 \u062f\u06cc\u062f\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/p><p>.3CC: \u062c\u0647\u0634 ARID1A\u060c \u00a0PI3KCA \u0648 KRAS \u00a0\u0634\u0627\u06cc\u0639 \u0627\u0633\u062a.<\/p><p>.4LGSC: KRAS \u0634\u0627\u06cc\u0639 \u0627\u0633\u062a.<\/p><p>.5MC: \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a CDKN2A\u060cKRAS \u00a0\u0648 \u00a0CDX2 \u0645\u0639\u0645\u0648\u0644 \u0647\u0633\u062a\u0646\u062f.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6512c9b e-con-full e-flex e-con e-child\" data-id=\"6512c9b\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u062a\u0648\u0636\u06cc\u062d\u0627\u062a \u062c\u062f\u0648\u0644 1. \u0632\u06cc\u0631\u06af\u0648\u0646\u0647\u200c\u0647\u0627: .1HGSC: \u0633\u0631\u0637\u0627\u0646 \u0633\u0631\u0648\u0632\u06cc \u0628\u0627 \u062f\u0631\u062c\u0647 \u0628\u0627\u0644\u0627 .2EC: \u0633\u0631\u0637\u0627\u0646 \u0627\u0646\u062f\u0648\u0645\u062a\u0631\u06cc\u0648\u0626\u06cc\u062f .3CC: \u0633\u0631\u0637\u0627\u0646 \u0633\u0644\u0648\u0644\u200c\u0647\u0627\u06cc \u0634\u0641\u0627\u0641 .4LGSC: \u0633\u0631\u0637\u0627\u0646 \u0633\u0631\u0648\u0632\u06cc \u0628\u0627 \u062f\u0631\u062c\u0647 \u067e\u0627\u06cc\u06cc\u0646 .5MC: \u0633\u0631\u0637\u0627\u0646 \u0645\u0648\u0633\u06cc\u0646\u0648\u0633 2. IHC Staining (\u0631\u0646\u06af\u200c\u0622\u0645\u06cc\u0632\u06cc \u0627\u06cc\u0645\u0646\u0648\u0647\u06cc\u0633\u062a\u0648\u0634\u06cc\u0645\u06cc): \u0646\u0634\u0627\u0646\u200c\u062f\u0647\u0646\u062f\u0647 \u0628\u06cc\u0627\u0646 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646\u200c\u0647\u0627\u06cc \u06a9\u0644\u06cc\u062f\u06cc \u0627\u0633\u062a. \u0639\u0644\u0627\u0645\u062a \u201c+\u201d \u06cc\u0639\u0646\u06cc \u0628\u06cc\u0627\u0646 \u0645\u062b\u0628\u062a\u060c \u201c-\u201d \u06cc\u0639\u0646\u06cc \u0645\u0646\u0641\u06cc\u060c \u0648 \u201c+\/-\u201d \u06cc\u0639\u0646\u06cc \u0645\u062a\u063a\u06cc\u0631 \u06cc\u0627 \u0646\u0627\u0642\u0635. 3. \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc: .1\u0633\u062a\u0648\u0646 \u00a0Molecular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-4392","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/evamed.ir\/ovarian-cancer\/wp-json\/wp\/v2\/posts\/4392","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/evamed.ir\/ovarian-cancer\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/evamed.ir\/ovarian-cancer\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/evamed.ir\/ovarian-cancer\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/evamed.ir\/ovarian-cancer\/wp-json\/wp\/v2\/comments?post=4392"}],"version-history":[{"count":4,"href":"https:\/\/evamed.ir\/ovarian-cancer\/wp-json\/wp\/v2\/posts\/4392\/revisions"}],"predecessor-version":[{"id":4397,"href":"https:\/\/evamed.ir\/ovarian-cancer\/wp-json\/wp\/v2\/posts\/4392\/revisions\/4397"}],"wp:attachment":[{"href":"https:\/\/evamed.ir\/ovarian-cancer\/wp-json\/wp\/v2\/media?parent=4392"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/evamed.ir\/ovarian-cancer\/wp-json\/wp\/v2\/categories?post=4392"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/evamed.ir\/ovarian-cancer\/wp-json\/wp\/v2\/tags?post=4392"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}